RASGRP1 antibody (AA 8-678)

Catalog No. ABIN7876843

The Rabbit Polyclonal anti-RASGRP1 antibody (ABIN7876843) specifically detects RASGRP1 in WB, ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for RASGRP1 antibody (AA 8-678) (ABIN7876843)

Target: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASGRP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-RASGRP1 Antibody

Binding Specificity: AA 8-678

Purpose: RASGRP1 Antibody / RAS guanyl-releasing protein 1

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids R8-Q678) was used as the immunogen for the RASGRP1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the RASGRP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the RASGRP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for RASGRP1

Target: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Alternative Name: RASGRP1

Background: RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene. This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).

UniProt: O95267

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway