KPNB1 antibody (AA 8-876)

Catalog No. ABIN7876847

This Mouse Monoclonal antibody specifically detects KPNB1 in WB, FACS, IF and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for KPNB1 antibody (AA 8-876) (ABIN7876847)

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This KPNB1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 3I11F2

Product Details anti-KPNB1 Antibody

Binding Specificity: AA 8-876

Purpose: KPNB1 Antibody / Importin subunit beta 1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids E8-A876) was used as the immunogen for the KPNB1 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the KPNB1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the KPNB1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for KPNB1

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Alternative Name: KPNB1

Background: Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene. Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene.

UniProt: Q14974

Pathways: Protein targeting to Nucleus