CPS1 antibody (AA 800-100)

Catalog No. ABIN7876864

The Mouse Monoclonal anti-CPS1 antibody (Clone CPS1-9869) (ABIN7876864) specifically detects CPS1 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for CPS1 antibody (AA 800-100) (ABIN7876864)

Target: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CPS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: CPS1-9869

Product Details anti-CPS1 Antibody

Binding Specificity: AA 800-100

Purpose: CPSase I Antibody / Carbamoyl phosphate synthetase 1 / CPS1 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 800-100 from human CPS1 protein was used as the immunogen for the CPSase I antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the CPSase I antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the CPSase I antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CPS1

Target: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Alternative Name: CPSase I

Background: This MAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

UniProt: P31327

Pathways: Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process