INPP5D antibody (AA 81-1093)

Catalog No. ABIN7876881

The Rabbit Polyclonal anti-INPP5D antibody is suitable to detect INPP5D in samples from Human. It has been validated for WB, ELISA and FACS.

Quick Overview for INPP5D antibody (AA 81-1093) (ABIN7876881)

Target: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INPP5D antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-INPP5D Antibody

Binding Specificity: AA 81-1093

Purpose: INPP5D Antibody / Inositol polyphosphate-5-phosphatase D / SHIP1

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids Q81-E1093) was used as the immunogen for the INPP5D antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the INPP5D antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the INPP5D antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for INPP5D

Target: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Alternative Name: INPP5D

Background: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 is an enzyme that in humans is encoded by the INPP5D gene. This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system.

UniProt: Q92835

Pathways: TCR Signaling, BCR Signaling, Warburg Effect