NYAP2 antibody (AA 83-617)

Catalog No. ABIN7876946

This Rabbit Polyclonal antibody specifically detects NYAP2 in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for NYAP2 antibody (AA 83-617) (ABIN7876946)

Target: NYAP2 (Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 2 (NYAP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NYAP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-NYAP2 Antibody

Binding Specificity: AA 83-617

Purpose: NYAP2 Antibody / Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human NYAP2 recombinant protein (Position: H83-L617) was used as the immunogen for the NYAP2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NYAP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the NYAP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for NYAP2

Target: NYAP2 (Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 2 (NYAP2))

Alternative Name: NYAP2

Background: NYAP2 antibody detects Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2, a brain-specific signaling adaptor protein involved in neuronal morphogenesis, axon guidance, and synaptic plasticity. The UniProt recommended name is Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 (NYAP2). This protein functions as a cytoplasmic adaptor linking guidance cues to the activation of PI3K pathways that regulate actin dynamics and neurite outgrowth.

Functionally, NYAP2 antibody identifies a 1,228-amino-acid neuronal protein that interacts with IRSp53 and PI3K subunits to transmit signals from axon guidance receptors such as neuregulin and contactin-associated proteins. NYAP2 participates in a signaling cascade involving Crk-associated substrate (CAS) and small GTPases Rac1 and Cdc42, controlling actin filament organization and neuronal polarity. It localizes to axons and growth cones, where it modulates cytoskeletal remodeling during neuronal wiring and plasticity.

The NYAP2 gene is located on chromosome 2q37.3 and is selectively expressed in brain regions including cortex, hippocampus, and cerebellum. Its expression peaks during neuronal differentiation and synapse formation, aligning with its role in neurodevelopment and synaptic function.

Pathologically, altered NYAP2 expression or mutation disrupts neuronal connectivity and has been associated with neurodevelopmental disorders such as autism spectrum disorder and intellectual disability. Dysregulation of NYAP2-mediated PI3K signaling may also contribute to synaptic dysfunction in neurodegenerative diseases. Research using NYAP2 antibody supports studies in neuronal signaling, actin cytoskeleton regulation, and brain development.

NYAP2 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect neuronal adaptor proteins. NSJ Bioreagents provides NYAP2 antibody reagents optimized for studies in axon guidance, synaptic signaling, and cytoskeletal remodeling.

Structurally, Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 contains multiple proline-rich motifs, SH3-binding regions, and tyrosine phosphorylation sites that enable dynamic interactions with signaling complexes. Its modular design allows integration of membrane receptor signals with intracellular actin regulatory machinery. This antibody facilitates exploration of NYAP2's function in neuronal network formation and synaptic communication.

UniProt: Q9P242