SNX16 antibody (AA 84-344)

Catalog No. ABIN7876956

The Rabbit Polyclonal anti-SNX16 antibody is suitable to detect SNX16 in samples from Human, Mouse and Rat. It has been validated for ELISA, WB, IHC, FACS, ICC and IF.

Quick Overview for SNX16 antibody (AA 84-344) (ABIN7876956)

Target: SNX16 (Sorting Nexin 16 (SNX16))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNX16 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-SNX16 Antibody

Binding Specificity: AA 84-344

Purpose: SNX16 Antibody / Sorting nexin-16

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human SNX16 recombinant protein (Position: I84-D344) was used as the immunogen for the SNX16 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SNX16 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SNX16 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SNX16

Target: SNX16 (Sorting Nexin 16 (SNX16))

Alternative Name: SNX16

Background: SNX16 antibody detects Sorting nexin-16, a phosphoinositide-binding protein that regulates endosomal trafficking, membrane remodeling, and receptor recycling. SNX16 belongs to the sorting nexin family, which is characterized by the presence of a phox homology (PX) domain that interacts with phosphatidylinositol 3-phosphate-enriched membranes. The SNX16 antibody is widely used in cell biology and neurobiology research to investigate endosome organization and cargo transport.

SNX16 is encoded by the SNX16 gene located on human chromosome 8p21.3. The protein is approximately 62 kilodaltons and localizes primarily to early endosomes. It participates in the formation of tubular endosomal structures that mediate receptor sorting between degradation and recycling pathways. SNX16 functions independently of the retromer complex and instead promotes membrane tubulation through its coiled-coil domain. It regulates trafficking of receptors such as EGFR and TrkB, influencing growth factor signaling and neuronal development.

The SNX16 antibody typically identifies a 40-50 kilodalton protein by western blot and demonstrates punctate cytoplasmic staining characteristic of endosomal localization. Functional studies show that depletion of SNX16 disrupts endosomal tubulation, alters cargo recycling, and can impair signaling pathways dependent on receptor localization. Overexpression of SNX16 enhances endosomal membrane curvature and promotes receptor clustering, demonstrating its mechanochemical role in shaping endosomes.

In neurons, SNX16 contributes to dendritic spine maintenance and receptor turnover, impacting synaptic plasticity. It may also participate in autophagy regulation through endosome-lysosome fusion. Aberrant SNX16 expression has been linked to neurodegenerative disorders and cancer, where altered trafficking pathways contribute to signaling dysregulation. NSJ Bioreagents offers a validated SNX16 antibody, enabling researchers to explore endosomal dynamics, cargo sorting, and signaling modulation.

UniProt: P57768