INHBA antibody (AA 85-112)

Catalog No. ABIN7876968

The Rabbit Polyclonal anti-INHBA antibody is suitable to detect INHBA in samples from Human. It has been validated for WB, IF, FACS and IHC (p).

Quick Overview for INHBA antibody (AA 85-112) (ABIN7876968)

Target: INHBA (Inhibin, beta A (INHBA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INHBA antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-INHBA Antibody

Binding Specificity: AA 85-112

Purpose: Inhibin beta A chain Antibody / INHBA

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 85-112 from the human protein was used as the immunogen for the Inhibin beta A chain antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Inhibin beta A chain antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Inhibin beta A chain antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for INHBA

Target: INHBA (Inhibin, beta A (INHBA))

Alternative Name: Inhibin beta A chain

Background: The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.

UniProt: P08476

Pathways: Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Autophagy