AXIN2 antibody (AA 86-812)

Catalog No. ABIN7877003

This Rabbit Polyclonal antibody specifically detects AXIN2 in IHC (p). It exhibits reactivity toward Zebrafish (Danio rerio).

Quick Overview for AXIN2 antibody (AA 86-812) (ABIN7877003)

Target: AXIN2 (Axin 2 (AXIN2))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AXIN2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-AXIN2 Antibody

Binding Specificity: AA 86-812

Purpose: Zebrafish Axin2 Antibody / Axis inhibition protein 2

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Axin2 recombinant protein (amino acids H86-D812) was used as the immunogen for the Zebrafish Axin2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Axin2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Axin2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for AXIN2

Target: AXIN2 (Axin 2 (AXIN2))

Alternative Name: Axin2

Background: Axin2 is a key scaffolding protein involved in the regulation of the Wnt/Beta-catenin signaling pathway, a critical pathway for cell fate determination, embryonic patterning, and tissue homeostasis. In zebrafish (Danio rerio), Axin2 serves as both a negative regulator and a transcriptional target of Wnt signaling, establishing it as a vital component in feedback control of the pathway.

Zebrafish axin2 is dynamically expressed during embryogenesis, particularly in regions undergoing active morphogenesis such as the neural tube, somites, and developing fins. By promoting the degradation of Beta-catenin, Axin2 attenuates Wnt signaling activity and ensures the precise spatial and temporal regulation of target gene expression. Its expression is commonly used as a molecular readout of Wnt/Beta-catenin pathway activity in vivo.

Because of its highly conserved role in Wnt signaling, zebrafish Axin2 is widely utilized in studies of developmental biology, stem cell regulation, tissue regeneration, and cancer research. It also serves as an important biomarker for monitoring Wnt pathway modulation in both genetic and pharmacological studies.

UniProt: P57095

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling