Recombinant CTNND1 antibody (AA 868-968)

Catalog No. ABIN7877009

This Mouse Monoclonal antibody specifically detects CTNND1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant CTNND1 antibody (AA 868-968) (ABIN7877009)

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CTNND1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RCTNND1-6903

Product Details anti-CTNND1 Antibody

Binding Specificity: AA 868-968

Purpose: Recombinant CTNND1 Antibody / p120 Catenin / Catenin delta 1

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 868-968 was used as the immunogen for the recombinant CTNND1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant CTNND1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant CTNND1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CTNND1

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Alternative Name: CTNND1

Background: Alpha-catenin and beta-catenin bind to the intracellular domain of E-cadherin while p120 catenin binds E-cadherin at a juxta-membrane site. The complex stabilizes tight junctions. In the cell, p120 catenin localized to the E-cadherin/catenins cell adhesion complex, directly associates with cytoplasmic C-terminus of E-cadherin and may similarly interact with other cadherins. p120 is a proliferation-associated nucleolar protein found in most human malignant tumors, but not in resting normal cells. In colorectal cancer the altered localization of p120 catenin corresponds with loss of cytoplasmic localization of E-cadherin. Studies have shown accurate categorization of ductal vs. lobular neoplasia in the breast was achieved with p120 staining. p120 expression further clarifies the separation of low-grade ductal carcinoma in situ from lobular neoplasia. Studies also have shown that altered expression of p120 catenin antibody predicts poor outcome in invasive breast cancer.

UniProt: O60716

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling