WISP2 antibody (AA 87-116)

Catalog No. ABIN7877011

The Rabbit Polyclonal anti-WISP2 antibody (ABIN7877011) specifically detects WISP2 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for WISP2 antibody (AA 87-116) (ABIN7877011)

Target: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WISP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-WISP2 Antibody

Binding Specificity: AA 87-116

Purpose: WISP-2 Antibody / WNT1-inducible-signaling pathway protein 2 / CCN5

Immunogen: A portion of amino acids 87-116 from the human protein was used as the immunogen for this WISP-2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the WISP-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the WISP-2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for WISP2

Target: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Alternative Name: WISP-2

Background: CCN5, also known as WISP-2 (Wnt-1-induced secreted protein 2), is a member of the CCN family of proteins that are involved in cell growth, differentiation, and migration. It is known for its ability to modulate signaling pathways that regulate various cellular activities, making it a key player in maintaining homeostasis in tissues. One of the primary functions of CCN5 is its role in regulating the growth and development of tissues, particularly in the cardiovascular system. Studies have shown that CCN5 can protect against cardiac fibrosis and hypertrophy, making it a potential therapeutic target for heart-related diseases. Furthermore, CCN5 has been found to have anti-inflammatory properties, making it a promising candidate for the treatment of inflammatory conditions. Its ability to regulate immune responses and modulate cytokine production highlights its potential as a target for managing inflammatory disorders. CCN5 has also been implicated in the regulation of metabolic processes and energy homeostasis. Research has shown that CCN5 can influence lipid metabolism and insulin sensitivity, suggesting its potential use in combating metabolic disorders such as obesity and diabetes.

UniProt: O76076

Pathways: WNT Signaling, Growth Factor Binding