EPH Receptor A4 antibody (AA 875-904)

Catalog No. ABIN7877022

The Rabbit Polyclonal anti-EPH Receptor A4 antibody is suitable to detect EPH Receptor A4 in samples from Human and Mouse. It has been validated for WB.

Quick Overview for EPH Receptor A4 antibody (AA 875-904) (ABIN7877022)

Target: EPH Receptor A4 (EPHA4)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EPH Receptor A4 Antibody

Binding Specificity: AA 875-904

Purpose: Ephrin type-A receptor 4 Antibody / EphA4

Purification: SAS precipitation

Immunogen: A portion of amino acids 875-904 from the human protein was used as the immunogen for the Ephrin type-A receptor 4 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Ephrin type-A receptor 4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot the Ephrin type-A receptor 4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for EPH Receptor A4

Target: EPH Receptor A4 (EPHA4)

Alternative Name: Ephrin type-A receptor 4

Background: Ephrin type-A receptor 4, also known as Eph4A, is a member of the Eph receptor family. These receptors are involved in mediating cell-to-cell communication and are critical for various physiological processes such as tissue patterning, neuronal development, and immune response. One of the key functions of Eph4A is its role in axon guidance during neuronal development. Studies have shown that Eph4A is essential for establishing proper neuronal connections in the developing brain. Disruption of Eph4A signaling has been linked to various neurological disorders, highlighting the importance of this receptor in brain development. In addition to its role in neuronal development, Eph4A has also been implicated in cancer progression. Aberrant expression of Eph4A has been observed in various types of cancer, and targeting this receptor has shown promising results in inhibiting tumor growth and metastasis. Furthermore, Eph4A has been shown to play a role in immune response regulation. By modulating the activity of immune cells, Eph4A can influence the inflammatory response and contribute to the maintenance of immune homeostasis.

UniProt: P54764

Pathways: RTK Signaling