SOGA2 antibody (AA 884-1522)

Catalog No. ABIN7877038

The Rabbit Polyclonal anti-SOGA2 antibody (ABIN7877038) specifically detects SOGA2 in WB, ELISA, IHC (p) and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SOGA2 antibody (AA 884-1522) (ABIN7877038)

Target: SOGA2 (SOGA Family Member 2 (SOGA2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOGA2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-SOGA2 Antibody

Binding Specificity: AA 884-1522

Purpose: MTCL1 Antibody / Microtubule cross-linking factor 1 / KIAA0802

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (K884-D1522) was used as the immunogen for the MTCL1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MTCL1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MTCL1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SOGA2

Target: SOGA2 (SOGA Family Member 2 (SOGA2))

Alternative Name: MTCL1

Background: MTCL1 (microtubule cross-linking factor 1), also known as CCDC165 (Coiledcoil domain-containing protein 165), SOGA2 or MTCL1, is a 1,905 amino acid protein that localizes to the cell membrane, cytoplasm and cytoskeleton. MTCL1 is a microtubule-associated factor that plays a role in regulating polarization and microtubule dynamics as well as the development and maintenance of non-centrosomal microtubule bundles. MTCL1 is encoded by a gene that maps to chromosome 18 and is expressed as four isoforms due to alternative splicing events. Chromosome 18 encodes over 300 genes and contains about 76 million bases. Trisomy 18, or Edwards syndrome, is the second most common trisomy after Downs syndrome. Symptoms of Edwards syndrome include low birth weight, a variety of physical development defects, heart deformations and breathing difficulty. Translocation between chromosome 18 and 14 is the most common translocation in cancers, and occurs in follicular lymphomas. Niemann-Pick disease, hereditary hemorrhagic telangiectasia and erythropoietic protoporphyria are associated with chromosome 18. The TGF? modulators, Smad2, Smad4 and Smad7 are encoded by chromosome 18.

UniProt: Q9Y4B5