MBNL1 antibody (AA 89-388)

Catalog No. ABIN7877057

This Rabbit Polyclonal antibody specifically detects MBNL1 in WB, ELISA, IF and IHC (p). It exhibits reactivity toward Human, Mouse, Rat and Monkey.

Quick Overview for MBNL1 antibody (AA 89-388) (ABIN7877057)

Target: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBNL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-MBNL1 Antibody

Binding Specificity: AA 89-388

Purpose: Muscleblind-like 1 Antibody / MBNL1

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids Q89-M388) was used as the immunogen for the Muscleblind-like 1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Muscleblind-like 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Muscleblind-like 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MBNL1

Target: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Alternative Name: Muscleblind-like 1

Background: Muscleblind-like (Drosophila), also known as MBNL1, is a protein that in humans is encoded by the MBNL1 gene. It is mapped to 3q25.1-q25.2. This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.

UniProt: Q9NR56

Pathways: Ribonucleoprotein Complex Subunit Organization