STXBP6 antibody (AA 9-176)

Catalog No. ABIN7877066

This Rabbit Polyclonal antibody specifically detects STXBP6 in WB, ELISA, IHC and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for STXBP6 antibody (AA 9-176) (ABIN7877066)

Target: STXBP6 (Syntaxin Binding Protein 6 (Amisyn) (STXBP6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STXBP6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Product Details anti-STXBP6 Antibody

Binding Specificity: AA 9-176

Purpose: STXBP6 Antibody / Syntaxin-binding protein 6

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human STXBP6 recombinant protein (Position: K9-R176) was used as the immunogen for the STXBP6 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the STXBP6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the STXBP6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for STXBP6

Target: STXBP6 (Syntaxin Binding Protein 6 (Amisyn) (STXBP6))

Alternative Name: STXBP6

Background: STXBP6 antibody detects Syntaxin-binding protein 6, also known as Amisyn, a vesicle trafficking protein that regulates membrane fusion and neurotransmitter release. STXBP6 interacts with syntaxin family members and SNARE complexes, modulating vesicular exocytosis and endocytosis. The STXBP6 antibody is widely used in neurobiology and cell trafficking research to study synaptic regulation, vesicle dynamics, and membrane fusion events.

STXBP6 is encoded by the STXBP6 gene located on human chromosome 14q23.2. The protein is approximately 246 amino acids long and contains coiled-coil domains that facilitate interaction with syntaxins such as STX1A and STX3. STXBP6 localizes to the cytoplasm and plasma membrane, where it competes with other SNARE regulators to fine-tune exocytic activity.

The STXBP6 antibody detects a 28 kilodalton band by western blot and shows cytoplasmic and perinuclear puncta consistent with vesicle-associated localization. In neurons, STXBP6 modulates neurotransmitter release by inhibiting SNARE complex assembly under resting conditions and promoting controlled vesicle fusion upon stimulation. Beyond the nervous system, STXBP6 regulates exocytosis in endocrine and epithelial cells, influencing hormone and transporter release.

Loss or dysregulation of STXBP6 affects vesicle cycling, leading to synaptic transmission defects and altered cellular signaling. In cancer cells, altered STXBP6 expression influences migration and invasion through effects on membrane recycling and adhesion molecule trafficking. It also plays roles in insulin granule exocytosis and endosomal trafficking in non-neuronal tissues.

As a modulator of vesicle docking and fusion, STXBP6 serves as a versatile model for understanding SNARE-mediated transport and signal propagation. NSJ Bioreagents provides a validated STXBP6 antibody optimized for its applications, supporting research into synaptic physiology, secretion, and membrane dynamics.

UniProt: Q8NFX7