SYCP1 antibody (AA 95-717)

Catalog No. ABIN7877226

The Rabbit Polyclonal anti-SYCP1 antibody is suitable to detect SYCP1 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for SYCP1 antibody (AA 95-717) (ABIN7877226)

Target: SYCP1 (Synaptonemal Complex Protein 1 (SYCP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYCP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SYCP1 Antibody

Binding Specificity: AA 95-717

Purpose: SYCP1 Antibody / Synaptonemal complex protein 1

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human SYCP1 recombinant protein (Position: D95-H717) was used as the immunogen for the SYCP1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SYCP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SYCP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SYCP1

Target: SYCP1 (Synaptonemal Complex Protein 1 (SYCP1))

Alternative Name: SYCP1

Background: SYCP1 antibody detects Synaptonemal complex protein 1, encoded by the SYCP1 gene. Synaptonemal complex protein 1 is a structural protein that forms the transverse filaments of the synaptonemal complex during meiosis. SYCP1 antibody provides researchers with a specific reagent for studying meiotic chromosome pairing, synapsis, and fertility.

Synaptonemal complex protein 1 plays a fundamental role in meiotic prophase I. Research using SYCP1 antibody has shown that it bridges homologous chromosomes by connecting lateral elements composed of SYCP2 and SYCP3. This zipper-like structure stabilizes pairing and promotes homologous recombination, ensuring proper segregation of chromosomes. Without SYCP1, homologous pairing fails, leading to meiotic arrest and infertility.

Studies with SYCP1 antibody have revealed that disruption of synaptonemal complex protein 1 causes sterility in both male and female model organisms. In humans, variants in SYCP1 have been linked to cases of infertility, demonstrating its conserved role in reproductive biology. Its structural role makes SYCP1 a key marker for meiotic progression.

Beyond meiosis, SYCP1 has been used as a biomarker for germ cell development. Research using SYCP1 antibody has shown that its expression is restricted to meiotic cells, allowing it to be used as a reliable marker for spermatogenesis and oogenesis studies. This makes SYCP1 antibody a valuable tool for developmental and reproductive biology research.

SYCP1 antibody is widely applied in immunohistochemistry, immunofluorescence, and western blotting. Immunohistochemistry highlights expression in testis and ovary, immunofluorescence demonstrates localization along meiotic chromosomes, and western blotting quantifies expression during gametogenesis. These applications make SYCP1 antibody indispensable for meiosis research.

By providing validated SYCP1 antibody reagents, NSJ Bioreagents supports studies into meiotic recombination, synaptonemal complex assembly, and infertility. Detection of Synaptonemal complex protein 1 provides researchers with insight into how meiotic structures safeguard chromosome segregation.

UniProt: Q15431