GZMM antibody (C-Term)

Catalog No. ABIN7877389

The Rabbit Polyclonal anti-GZMM antibody (ABIN7877389) specifically detects GZMM in IHC. The antibody is reactive with Human samples.

Quick Overview for GZMM antibody (C-Term) (ABIN7877389)

Target: GZMM (Granzyme M (Lymphocyte Met-Ase 1) (GZMM))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GZMM antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-GZMM Antibody

Binding Specificity: C-Term

Purpose: GZMM Antibody / Granzyme M

Purification: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Granzyme M/GZMM was used as the immunogen for the GZMM antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GZMM antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GZMM antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GZMM

Target: GZMM (Granzyme M (Lymphocyte Met-Ase 1) (GZMM))

Alternative Name: GZMM

Background: GZMM antibody detects Granzyme M, a serine protease expressed in cytotoxic lymphocytes and natural killer (NK) cells that mediates immune defense through target cell apoptosis. The UniProt recommended name is Granzyme M (GZMM). This enzyme contributes to innate immunity by inducing non-caspase-dependent cell death and by modulating inflammatory cytokine processing.

Functionally, GZMM antibody identifies a 262-amino-acid protein localized to cytotoxic granules of NK and CD8+ T cells. Granzyme M is stored in secretory vesicles and released upon immune activation to cleave intracellular substrates in infected or malignant cells. It works synergistically with perforin and other granzymes to initiate rapid target cell lysis.

The GZMM gene is located on chromosome 19p13.3 within the granzyme gene cluster and is expressed predominantly in NK cells and cytotoxic T lymphocytes. GZMM contributes to immune surveillance by degrading viral and bacterial proteins and modulating proinflammatory signaling pathways.

Pathologically, elevated GZMM activity has been observed in inflammatory and autoimmune diseases, as well as in cancer immune responses. Deficiency impairs cytotoxic clearance of pathogens and tumor cells. Research using GZMM antibody supports studies in immunology, cytotoxic signaling, and inflammation control.

GZMM antibody is validated for western blotting, flow cytometry, and immunohistochemistry to detect cytotoxic granule enzymes. NSJ Bioreagents provides GZMM antibody reagents optimized for immune cell function, cytotoxicity, and inflammation research.

Structurally, Granzyme M is a trypsin-like serine protease containing the catalytic triad His-Asp-Ser and a substrate-binding pocket that determines cleavage specificity. This antibody aids in examining GZMM's role in cytotoxic defense and immune regulation.

UniProt: P51124