Cytokeratin 1 antibody (C-Term)

Catalog No. ABIN7877406

The Mouse Monoclonal anti-Cytokeratin 1 antibody is suitable to detect Cytokeratin 1 in samples from Human and Rat. It has been validated for IHC (p).

Quick Overview for Cytokeratin 1 antibody (C-Term) (ABIN7877406)

Target: Cytokeratin 1 (KRT1) (Keratin 1 (KRT1))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cytokeratin 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: LHK1

Product Details anti-Cytokeratin 1 Antibody

Binding Specificity: C-Term

Purpose: Cytokeratin 1 Antibody / CK1 / Keratin 1

Sequence: VRFVSTSYSG VTR

Purification: Protein G affinity chromatography

Immunogen: Amino acids VRFVSTSYSGVTR from the C-terminal portion of the protein was used as the immunogen for this Cytokeratin 1 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the Cytokeratin 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Cytokeratin 1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Cytokeratin 1

Target: Cytokeratin 1 (KRT1) (Keratin 1 (KRT1))

Alternative Name: Cytokeratin 1

Background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Cytokeratin 1 is a hetero-tetramer of two type I as well as two type II keratins, keratin-10 (KRT10). Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epithelia. Mutations in keratin 1 cause epidermolytic hyperkeratosis.

UniProt: P04264