BTLA antibody (Extracellular)

Catalog No. ABIN7877535

The Mouse Monoclonal anti-BTLA antibody is suitable to detect BTLA in samples from Human. It has been validated for ELISA.

Quick Overview for BTLA antibody (Extracellular) (ABIN7877535)

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BTLA antibody is un-conjugated

Application: ELISA

Clone: BTLA-1528

Product Details anti-BTLA Antibody

Binding Specificity: Extracellular

Purpose: BTLA Antibody / CD272

Purification: Protein G affinity chromatography

Immunogen: Recombinant extracellular human CD272/BTLA protein was used as the immunogen for this BTLA antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the BTLA antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the BTLA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for BTLA

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Alternative Name: BTLA

Background: B and T lymphocyte attenuator (BTLA) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T-cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are coinhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T-cell activation by propagating inhibitory signals through BTLA. The BTLAHVEM interaction is conserved between Mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation.

UniProt: Q7Z6A9

Pathways: Cancer Immune Checkpoints