ISR-alpha antibody (Extracellular)

Catalog No. ABIN7877548

The Mouse Monoclonal anti-ISR-alpha antibody (Clone INSR-1661) (ABIN7877548) specifically detects ISR-alpha in ELISA. The antibody is reactive with Human samples.

Quick Overview for ISR-alpha antibody (Extracellular) (ABIN7877548)

Target: ISR-alpha (Insulin Receptor alpha (ISR-alpha))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ISR-alpha antibody is un-conjugated

Application: ELISA

Clone: INSR-1661

Product Details anti-ISR-alpha Antibody

Binding Specificity: Extracellular

Purpose: Insulin Receptor alpha Antibody

Purification: Protein G affinity chromatography

Immunogen: A recombinant fragment from the extracellular domain of human Insulin Receptor alpha was used as the immunogen for this Insulin Receptor alpha antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Insulin Receptor alpha antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Insulin Receptor alpha antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for ISR-alpha

Target: ISR-alpha (Insulin Receptor alpha (ISR-alpha))

Alternative Name: Insulin Receptor alpha

Background: The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.

UniProt: P06213