Recombinant YWHAE antibody (full length)

Catalog No. ABIN7877579

This Mouse Monoclonal antibody specifically detects YWHAE in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant YWHAE antibody (full length) (ABIN7877579)

Target: YWHAE (14-3-3 epsilon (YWHAE))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This YWHAE antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RYWHAE-8860

Product Details anti-YWHAE Antibody

Binding Specificity: full length

Purpose: Recombinant YWHAE Antibody / 14-3-3E

Purification: Protein A/G affinity

Immunogen: Recombinant human full-length protein was used as the immunogen for the recombinant YWHAE antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant YWHAE antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant YWHAE antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for YWHAE

Target: YWHAE (14-3-3 epsilon (YWHAE))

Alternative Name: YWHAE

Background: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. The YWHAE gene which encodes 14-3-3E has also been identified as a possible susceptibility gene for schizophrenia.

UniProt: P62258

Pathways: Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, M Phase