alpha Actinin 4 antibody (full length)

Catalog No. ABIN7877605

The Mouse Monoclonal anti-alpha Actinin 4 antibody (Clone 93) (ABIN7877605) specifically detects alpha Actinin 4 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for alpha Actinin 4 antibody (full length) (ABIN7877605)

Target: alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This alpha Actinin 4 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 93

Product Details anti-alpha Actinin 4 Antibody

Binding Specificity: full length

Purpose: Alpha Actinin 4 Antibody / ACTN4

Purification: Protein G affinity chromatography

Immunogen: A recombinant full-length human ACTN4 protein was used as the immunogen for this Alpha Actinin 4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Alpha Actinin 4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Alpha Actinin 4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for alpha Actinin 4

Target: alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Alternative Name: Alpha Actinin 4

Background: The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and -actinins. There are four tissue-specific -actinins, namely -actinin-1, -actinin-2, -actinin-3 and -actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each -actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding -actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.

UniProt: O43707

Pathways: Proton Transport