BCL11A antibody (full length)

Catalog No. ABIN7877692

The Mouse Monoclonal anti-BCL11A antibody (Clone PCRP-BCL11A-1G10) (ABIN7877692) specifically detects BCL11A in WB, ELISA, IF and FACS. The antibody is reactive with Human samples.

Quick Overview for BCL11A antibody (full length) (ABIN7877692)

Target: BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BCL11A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Grade: Carrier-free

Clone: PCRP-BCL11A-1G10

Product Details anti-BCL11A Antibody

Binding Specificity: full length

Purpose: BCL11A Antibody / B-cell lymphoma/leukemia 11A (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the BCL11A antibody.

Isotype: IgG2a

Application Details

Application Notes: Optimal dilution of the BCL11A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the BCL11A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for BCL11A

Target: BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))

Alternative Name: BCL11A

Background: Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.

UniProt: Q9H165

Pathways: Regulation of Cell Size