Calcineurin B antibody (full length)

Catalog No. ABIN7877754

The Mouse Monoclonal anti-Calcineurin B antibody is suitable to detect Calcineurin B in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for Calcineurin B antibody (full length) (ABIN7877754)

Target: Calcineurin B (CAN)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Calcineurin B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: BE2-1

Product Details anti-Calcineurin B Antibody

Binding Specificity: full length

Purpose: Calcineurin B Antibody / PPP3R1

Purification: Protein G affinity chromatography

Immunogen: A recombinant full-length human Calcineurin B protein was used as the immunogen for the Calcineurin B antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the Calcineurin B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Calcineurin B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Calcineurin B

Target: Calcineurin B (CAN)

Alternative Name: Calcineurin B

Background: Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.

UniProt: P63098

Pathways: Cellular Glucan Metabolic Process, VEGF Signaling