Calpastatin antibody (full length)

Catalog No. ABIN7877762

This Mouse Monoclonal antibody specifically detects Calpastatin in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Calpastatin antibody (full length) (ABIN7877762)

Target: Calpastatin (CAST)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Calpastatin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CAST-1550

Product Details anti-Calpastatin Antibody

Binding Specificity: full length

Purpose: Calpastatin Antibody

Purification: Protein G affinity chromatography

Immunogen: A recombinant full-length human CAST protein was used as the immunogen for this Calpastatin antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Calpastatin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Calpastatin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Calpastatin

Target: Calpastatin (CAST)

Alternative Name: Calpastatin

Background: Calpastatin is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpastatin, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpastatin co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.

UniProt: P20810