Recombinant beta Catenin antibody (full length)

Catalog No. ABIN7877826

The Mouse Monoclonal anti-beta Catenin antibody is suitable to detect beta Catenin in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant beta Catenin antibody (full length) (ABIN7877826)

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta Catenin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: RCTNNB1-7358

Product Details anti-beta Catenin Antibody

Binding Specificity: full length

Purpose: Recombinant Catenin Beta Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human Beta-Catenin/CTNNB1 protein was used as the immunogen for the recombinant Catenin Beta antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Catenin Beta antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the recombinant Catenin Beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for beta Catenin

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Alternative Name: Catenin Beta

Background: Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.

UniProt: P35222

Pathways: Peptide Hormone Metabolism