CD34 antibody (full length)

Catalog No. ABIN7877864

This Mouse Monoclonal antibody specifically detects CD34 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for CD34 antibody (full length) (ABIN7877864)

Target: CD34

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD34 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: CD34-4939

Product Details anti-CD34 Antibody

Binding Specificity: full length

Purpose: CD34 Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human HPCA1 protein was used as the immunogen for the CD34 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CD34 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the CD34 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CD34

Target: CD34

Alternative Name: CD34

Background: This MAb recognizes a single chain, transmembrane,heavily glycosylated protein of 90-120 kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified intothree main categories, class I, class II and class III. It is a class II antibody whose epitope is resistant to neuraminidasebut sensitive to glycoprotease and chymopapain.CD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. It appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels 85 % of angiosarcoma and Kaposi s sarcoma, but with a lower specificity.

UniProt: P28906