CD63 antibody (full length) (CF®488A)

Catalog No. ABIN7877944

The CF®488A-conjugated Mouse Monoclonal anti-CD63 antibody (Clone MX-49-129-5) (ABIN7877944) specifically detects CD63 in FACS and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for CD63 antibody (full length) (CF®488A) (ABIN7877944)

Target: CD63

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD63 antibody is conjugated to CF®488A

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: MX-49-129-5

Product Details anti-CD63 Antibody (CF®488A)

Binding Specificity: full length

Purpose: CD63 Antibody / LAMP-3

Purification: Protein G affinity chromatography

Immunogen: Full length human CD63 was used as the immunogen for this antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CD63 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 500 µL at 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the CD63 antibody at 2-8oC, protected from light.

Target Details for CD63

Target: CD63

Alternative Name: CD63

Background: This MAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.

UniProt: P08962