Recombinant Complement C4d antibody (full length)

Catalog No. ABIN7877993

This Rabbit Monoclonal antibody specifically detects Complement C4d in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant Complement C4d antibody (full length) (ABIN7877993)

Target: Complement C4d (C4d) (Complement Component C4d (C4d))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Complement C4d antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: C4D-9213R

Product Details anti-Complement C4d Antibody

Binding Specificity: full length

Purpose: Recombinant Complement 4d Antibody / C4d (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human Complement 4d protein was used as the immunogen for the recombinant Complement 4d antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Complement 4d antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Aliquot the recombinant Complement 4d antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Complement C4d

Target: Complement C4d (C4d) (Complement Component C4d (C4d))

Alternative Name: Complement 4d

Background: This MAb is specific to Complement 4d (C4d) and reacts with the secreted as well as cell-bound C4d. C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 Molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment.

UniProt: P0C0L4