ERG
Reactivity: Human
IHC, ELISA, IF, IP
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Optimal dilution of the ERG antibody should be determined by the researcher.
Restrictions
For Research Use only
Format
Liquid
Concentration
1 mg/mL
Buffer
1 mg/mL in 1X PBS, BSA free, sodium azide free
Preservative
Azide free
Storage
-20 °C
Storage Comment
Aliquot the ERG antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Target
ERG
(ERG, ETS transcription factor (ERG))
Alternative Name
ERG
Background
The transcription factor erythroblastosis virus E26 transforming sequence related gene (ERG) functions as a regulator of key cellular functions to promote endothelial homeostasis. Expression of ERG has been observed in both benign and malignant vascular endothelial tumors, such as hemangiomas and Kaposi sarcomas, respectively. Carcinomas of the breast, colon, and urothelium have demonstrated absence of ERG expression, whereas presence of the protein has been confirmed in a subset of prostate carcinoma cases. Anti-ERG can be a useful tool for identifying vascular endothelial neoplasms and distinguishing prostate carcinoma from epithelial tumors of non-prostatic origin.