Recombinant FLI1 antibody (full length)

Catalog No. ABIN7878256

The Rabbit Monoclonal anti-FLI1 antibody (Clone FLI1-4371R) (ABIN7878256) specifically detects FLI1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant FLI1 antibody (full length) (ABIN7878256)

Target: FLI1 (Friend Leukemia Virus Integration 1 (FLI1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This FLI1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: FLI1-4371R

Product Details anti-FLI1 Antibody

Binding Specificity: full length

Purpose: FLI1 Antibody (azide and preservative free)

Purification: Protein A affinity

Immunogen: Recombinant full-length human FLI1 protein was used as the immunogen for the FLI1 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the FLI1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the FLI1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for FLI1

Target: FLI1 (Friend Leukemia Virus Integration 1 (FLI1))

Alternative Name: FLI1

Background: Recognizes a protein of 51 kDa, which is identified as FLI1. This protein, a member of the ETS family of DNA binding transcription factors, is involved in cellular proliferation and tumorigenesis. Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90 % of Ewing s Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11,22)(q24,q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi s Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.

UniProt: Q01543