Gastrin antibody (full length)

Catalog No. ABIN7878264

The Mouse Monoclonal anti-Gastrin antibody is suitable to detect Gastrin in samples from Human. It has been validated for IHC (p).

Quick Overview for Gastrin antibody (full length) (ABIN7878264)

Target: Gastrin (GAST)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Gastrin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: GAST-2634

Product Details anti-Gastrin Antibody

Binding Specificity: full length

Purpose: Gastrin Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A recombinant full-length human GAST protein was used as the immunogen for this Gastrin antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Gastrin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Gastrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Gastrin

Target: Gastrin (GAST)

Alternative Name: Gastrin

Background: Gastrin, is a hormone that normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets. Its primary function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. It also responsible for stimulating smooth muscle contraction and increasing blood circulation and water secretion in the stomach and intestine. Gastrin is regulated by epidermal growth factor in both mice and humans. Gastrin is excreted in excess by pancreatic tumors in the Zollinger-Ellison syndrome. Gastrin-Releasing Peptide (GRP) stimulates the release of gastrin as well as other gastrointestinal hormones and also acts as an autocrine growth factor for certain cell types. High levels of GRP are found in the human lung just after birth and levels decrease thereafter in parallel with the observed disease in a number of pulmonary neuroendocrine cells. GRP is known to promote lung tumorigenesis in model systems.

UniProt: P01350