GCLM antibody (full length)

Catalog No. ABIN7878298

The Mouse Monoclonal anti-GCLM antibody (Clone GCLM-4069) (ABIN7878298) specifically detects GCLM in IHC (p). The antibody is reactive with Human samples.

Quick Overview for GCLM antibody (full length) (ABIN7878298)

Target: GCLM (Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GCLM antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: GCLM-4069

Product Details anti-GCLM Antibody

Binding Specificity: full length

Purpose: GLCLR Antibody / GCLM (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human GLCLR protein was used as the immunogen for the GCLM antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the GLCLR antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the GLCLR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GCLM

Target: GCLM (Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))

Alternative Name: GLCLR

Background: G-glutamylcysteine synthetase (g-GCS) is the rate limiting enzyme for glutathione (L-g-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. g-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. The human g-GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human g-GCS gene encoding the regulatory subunit maps to chromosome 1p22.1. The two subunits of g-GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond.

UniProt: P48507