Recombinant GSTM3 antibody (full length)

Catalog No. ABIN7878302

This Mouse Monoclonal antibody specifically detects GSTM3 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant GSTM3 antibody (full length) (ABIN7878302)

Target: GSTM3 (Glutathione S-Transferase mu 3 (Brain) (GSTM3))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GSTM3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: RGSTM3-8878

Product Details anti-GSTM3 Antibody

Binding Specificity: full length

Purpose: Recombinant GSTM3 Antibody / Glutathione S-Transferase Mu3 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human GSTM3 protein was used as the immunogen for the recombinant GSTM3 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the recombinant GSTM3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the recombinant GSTM3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GSTM3

Target: GSTM3 (Glutathione S-Transferase mu 3 (Brain) (GSTM3))

Alternative Name: GSTM3

Background: Members of the glutathione S-transferase (GST) family of proteins function in the detoxification of xenobiotics to protect cells against toxicant-induced damage. There are eight families of GST proteins, each of which are composed of proteins that have a variety of functions throughout the cell. The GSTM proteins (GSTM1-GSTM5 in human and GSTM1-GSTM7 in mouse) are members of the mu class of enzymes that conjugate with glutathione and function in the detoxification of carcinogens, environmental toxins and products of oxidative stress. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. GSTM3 protein is selectively expressed in the testis and brain. GSTM3 may also be tumor suppressive in RCC, as low expression has been demonstrated to correlate with RCC risk and poor prognosis in post-op patients.

UniProt: P21266