Recombinant CGA antibody (full length)

Catalog No. ABIN7878307

The Mouse Monoclonal anti-CGA antibody (Clone rCHGA-9612) (ABIN7878307) specifically detects CGA in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant CGA antibody (full length) (ABIN7878307)

Target: CGA (Glycoprotein Hormones, alpha Polypeptide (CGA))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CGA antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RCHGA-9612

Product Details anti-CGA Antibody

Binding Specificity: full length

Purpose: Recombinant CgA Antibody / Chromogranin A

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human Chromogranin A protein was used as the immunogen for the recombinant CgA antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the recombinant CgA antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant CgA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CGA

Target: CGA (Glycoprotein Hormones, alpha Polypeptide (CGA))

Alternative Name: CgA

Background: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

UniProt: P10645

Pathways: Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport, Peptide Hormone Metabolism