Recombinant ATRX antibody (full length)

Catalog No. ABIN7878361

The Mouse Monoclonal anti-ATRX antibody (Clone rATRX-3446) (ABIN7878361) specifically detects ATRX in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant ATRX antibody (full length) (ABIN7878361)

Target: ATRX (helicase 2, X-linked (ATRX))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATRX antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: RATRX-3446

Product Details anti-ATRX Antibody

Binding Specificity: full length

Purpose: Recombinant ATRX Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Recombinant full-length human ATRX protein was used as the immunogen for the recombinant ATRX antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant ATRX antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant ATRX antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Alternative Name: ATRX

Background: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 thalassemia or ATRX syndrome

UniProt: P46100