Recombinant ATRX antibody (full length)

Catalog No. ABIN7878362

This Mouse Monoclonal antibody specifically detects ATRX in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant ATRX antibody (full length) (ABIN7878362)

Target: ATRX (helicase 2, X-linked (ATRX))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATRX antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RATRX-3446

Product Details anti-ATRX Antibody

Binding Specificity: full length

Purpose: Recombinant ATRX Antibody

Purification: Protein G affinity chromatography

Immunogen: Recombinant full-length human ATRX protein was used as the immunogen for the recombinant ATRX antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant ATRX antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant ATRX antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Alternative Name: ATRX

Background: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 thalassemia or ATRX syndrome

UniProt: P46100