ATRX antibody (full length)

Catalog No. ABIN7878364

The Mouse Monoclonal anti-ATRX antibody (Clone ATRX-7940) (ABIN7878364) specifically detects ATRX in IHC (p). The antibody is reactive with Human samples.

Quick Overview for ATRX antibody (full length) (ABIN7878364)

Target: ATRX (helicase 2, X-linked (ATRX))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATRX antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ATRX-7940

Product Details anti-ATRX Antibody

Binding Specificity: full length

Purpose: ATRX Antibody / RAD54

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human ATRX protein was used as the immunogen for the ATRX antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ATRX antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the ATRX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Alternative Name: ATRX

Background: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with thalassemia or ATRX syndrome .

UniProt: P46100