IGFBP3 antibody (full length)

Catalog No. ABIN7878422

This Mouse Monoclonal antibody specifically detects IGFBP3 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for IGFBP3 antibody (full length) (ABIN7878422)

Target: IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IGFBP3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IGFBP3-3423

Product Details anti-IGFBP3 Antibody

Binding Specificity: full length

Purpose: Insulin-like growth factor-binding protein 3 Antibody / IGFBP3

Purification: Protein A/G affinity

Immunogen: Recombinant human full-length IGFBP3 protein was used as the immunogen for the Insulin-like growth factor-binding protein 3 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Insulin-like growth factor-binding protein 3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Insulin-like growth factor-binding protein 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IGFBP3

Target: IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

Alternative Name: Insulin-like growth factor-binding protein 3

Background: The Insulin-like growth factor-binding proteins, or IGFBPs, are a family of homologous proteins that have co-evolved with the IGFs. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, as well as their concentration and distribution in the extracellular environment. In addition, the IGFBPs appear to have biological activity independent of the IGFs. Seven IGFBPs have thus far been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. IGFBP3 is the most abundant IGFBP and is complexed with roughly 80 % of the serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury.

UniProt: P17936

Pathways: Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding