Recombinant Involucrin antibody (full length)

Catalog No. ABIN7878460

The Mouse Monoclonal anti-Involucrin antibody (Clone rIVRN-827) (ABIN7878460) specifically detects Involucrin in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant Involucrin antibody (full length) (ABIN7878460)

Target: Involucrin (IVL)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Involucrin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: RIVRN-827

Product Details anti-Involucrin Antibody

Binding Specificity: full length

Purpose: Recombinant Involucrin Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A recombinant human full-length Involucrin protein was used as the immunogen for this recombinant Involucrin antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Involucrin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant Involucrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Involucrin

Target: Involucrin (IVL)

Alternative Name: Involucrin

Background: It recognizes a protein of 66 kDa-170 kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120 kDa protein. It stains the involucrin in a variety of sizes: 170 kDa in MCF-7 cells, a doublet of ~115 kDa and 150 kDa in gorilla and owl monkey, 66 kDa in dog, and a doublet of 105 kDa in pig. Its epitope maps between codon 421-568 of human involucrin. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal, expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.

UniProt: P07476