Keratin 10 antibody (full length)

Catalog No. ABIN7878475

The Mouse Monoclonal anti-Keratin 10 antibody (Clone KRT10-3861) (ABIN7878475) specifically detects Keratin 10 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Keratin 10 antibody (full length) (ABIN7878475)

Target: Keratin 10 (KRT10)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Keratin 10 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: KRT10-3861

Product Details anti-Keratin 10 Antibody

Binding Specificity: full length

Purpose: Keratin 10 Antibody / Cytokeratin 10 / CK10

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human KRT10 protein was used as the immunogen for the Keratin 10 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Keratin 10 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Keratin 10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Keratin 10

Target: Keratin 10 (KRT10)

Alternative Name: Keratin 10

Background: This mAb recognizes a protein of 56.5 kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation, it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more differentiated parts.

UniProt: P13645