Recombinant LAMP3 antibody (full length)

Catalog No. ABIN7878547

The Rabbit Monoclonal anti-LAMP3 antibody (Clone LAMP3-8678R) (ABIN7878547) specifically detects LAMP3 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant LAMP3 antibody (full length) (ABIN7878547)

Target: LAMP3 (Lysosomal-Associated Membrane Protein 3 (LAMP3))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This LAMP3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: LAMP3-8678R

Product Details anti-LAMP3 Antibody

Binding Specificity: full length

Purpose: Recombinant LAMP-3 Antibody / CD63

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the recombinant LAMP-3 antibody. Its epitope is different from that of mAb LAMP3/529.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant LAMP-3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant LAMP-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for LAMP3

Target: LAMP3 (Lysosomal-Associated Membrane Protein 3 (LAMP3))

Alternative Name: LAMP-3

Background: This mAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63. Its epitope is different from that of mAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.

UniProt: P08962