MXI1 antibody (full length)

Catalog No. ABIN7878586

The Mouse Monoclonal anti-MXI1 antibody (Clone PCRP-MXI1-1A3) (ABIN7878586) specifically detects MXI1 in WB, IF and FACS. The antibody is reactive with Human samples.

Quick Overview for MXI1 antibody (full length) (ABIN7878586)

Target: MXI1 (MAX Interactor 1 (MXI1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MXI1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Grade: Carrier-free

Clone: PCRP-MXI1-1A3

Product Details anti-MXI1 Antibody

Binding Specificity: full length

Purpose: MXI1 Antibody / Max-interacting protein 1 / BHLHC11 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human MXI1 protein was used as the immunogen for the MXI1 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the MXI1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the MXI1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for MXI1

Target: MXI1 (MAX Interactor 1 (MXI1))

Alternative Name: MXI1

Background: It is now well established that Myc regulation of cell proliferation and differentiation involves a family of related transcription factors. One such factor, Max, is an obligate heterodimeric partner for Myc and can also form heterodimers with at least four related proteins designated Mad 1, Mxi1 (also designated Mad 2), Mad 3 and Mad 4. Like Mad 1 and Mxi1, association of Mad 3 and Mad 4 with Max results in transcriptional repression. Both Myc and the Mad proteins have short half-lives and their synthesis is tightly regulated, while Max expression is constitutive and relatively stable. Two related mammalian cDNAs have been identified and shown to encode Mad- binding proteins. Both possess sequence homology with the yeast transcription repressor Sin3 including four conserved paired amphipathic helix (PAH) domains. mSin3A and mSin3B specifically interact with the Mad proteins via their second paired amphipathic helix domain (PAH2). It has been suggested that Mad-Max heterodimers repress transcription by tethering mSin3 to DNA as corepressors.

UniProt: P50539

Pathways: Maintenance of Protein Location