MPZ antibody (full length)

Catalog No. ABIN7878684

The Mouse Monoclonal anti-MPZ antibody is suitable to detect MPZ in samples from Human. It has been validated for IHC (p).

Quick Overview for MPZ antibody (full length) (ABIN7878684)

Target: MPZ (Myelin Protein Zero (MPZ))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MPZ antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MPZ-7389

Product Details anti-MPZ Antibody

Binding Specificity: full length

Purpose: Myelin Protein Zero Antibody / MPZ

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human MPZ protein was used as the immunogen for the Myelin Protein Zero antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the Myelin Protein Zero antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Myelin Protein Zero antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for MPZ

Target: MPZ (Myelin Protein Zero (MPZ))

Alternative Name: Myelin Protein Zero

Background: Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50 % of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.

UniProt: P25189