Peroxiredoxin 4 antibody (full length)

Catalog No. ABIN7878792

The Mouse Monoclonal anti-Peroxiredoxin 4 antibody is suitable to detect Peroxiredoxin 4 in samples from Human. It has been validated for ELISA.

Quick Overview for Peroxiredoxin 4 antibody (full length) (ABIN7878792)

Target: Peroxiredoxin 4 (PRDX4)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Peroxiredoxin 4 antibody is un-conjugated

Application: ELISA

Clone: CPTC-PRDX4-1

Product Details anti-Peroxiredoxin 4 Antibody

Binding Specificity: full length

Purpose: Peroxiredoxin 4 Antibody / PRDX4

Purification: Protein G affinity

Immunogen: A recombinant full-length human PRDX4 protein was used as the immunogen for the Peroxiredoxin 4 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the Peroxiredoxin 4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot the Peroxiredoxin 4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Peroxiredoxin 4

Target: Peroxiredoxin 4 (PRDX4)

Alternative Name: Peroxiredoxin 4

Background: The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX IV gene is expressed in many tissues. It exists as a precursor protein, which is only detected in testis, and aprocessed secreted form. PRX IV is highly expressed in lung cancer and is necessary for the promotion of lung cancer in vitro. Studies have demonstrated that PRX IV positive expression is significantly correlated with recurrences and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma, and therefore can be used as a prognostic marker in lung squamous cell carcinoma.

UniProt: Q13162