PRDM1 antibody (full length)

Catalog No. ABIN7878834

The Mouse Monoclonal anti-PRDM1 antibody is suitable to detect PRDM1 in samples from Human. It has been validated for FACS and IF.

Quick Overview for PRDM1 antibody (full length) (ABIN7878834)

Target: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRDM1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: PCRP-PRDM1-2B9

Product Details anti-PRDM1 Antibody

Binding Specificity: full length

Purpose: BLIMP-1 Antibody / PRDM1

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the BLIMP-1 antibody.

Isotype: IgG2a

Application Details

Application Notes: Optimal dilution of the BLIMP-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the BLIMP-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PRDM1

Target: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Alternative Name: BLIMP-1

Background: The development and differentiation of plasma cells, which are terminally differentiated B-cells, are induced by Blimp-1 (B lymphocyte-induced maturation protein, also designated PRDI-BF1). Blimp-1 is a transcriptional repressor that localizes to the nucleus and is considered a master regulator of terminal B-cell development. Alone, Blimp-1 is sufficient to trigger terminal B-cell differentiation. Blimp-1 upregulates the expression of syndecan-1 and J chain, represses IFN-b gene transcription and associates with HDAC to recruit it to DNA, thereby repressing c-Myc. Blimp-1 is expressed during the late stages of B-cell differentiation in immunoglobulin-secreting plasma cells, as well as in long-lived, bone marrow plasma cells. The expression of Blimp-1 defines a checkpoint beyond which fully activated B cells proceed to the plasma cell stage, whereas immature and partially activated cells are eliminated.

UniProt: O75626

Pathways: Regulation of Muscle Cell Differentiation