PRMT6 antibody (full length)

Catalog No. ABIN7878875

This Mouse Monoclonal antibody specifically detects PRMT6 in IF and FACS. It exhibits reactivity toward Human.

Quick Overview for PRMT6 antibody (full length) (ABIN7878875)

Target: PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRMT6 antibody is un-conjugated

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-PRMT6-2C9

Product Details anti-PRMT6 Antibody

Binding Specificity: full length

Purpose: PRMT6 Antibody

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human PRMT6 protein was used as the immunogen for the PRMT6 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the PRMT6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the PRMT6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PRMT6

Target: PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))

Alternative Name: PRMT6

Background: A class of proteins termed type 1 protein arginine N-methyltransferase (PRMT) enzymes contribute to posttranslational modification of RNA-binding proteins, but differ in substrate specificities, oligomerization properties and subcellular localization. PRMTs contain an S-adenosylmethione motif which functions to add one or two methyl groups to guanidino nitrogens of arginine (R) side chains. PRMT6, also known as HRMT1L6, is a nuclear protein belonging to the PRMT family and is predominantly expressed in testis and kidney. It is known to methylate Histones H3, H4 and H2A. PRMT6 is the major dimethyltransferase for Histone H3 and specifically methylates Histone H3 at R2. Methylation at Histone H3 R2 acts to inhibit Histone H3 K4 trimethylation and ultimately leads to the transcriptional repression of genes that are activated by Histone H3 K4 trimethylation. In addition, PRMT6 methylates HIV TAT, possibly functioning as a form of cellular innate immunity to restrict levels of HIV replication.

UniProt: Q96LA8