QKI antibody (full length)

Catalog No. ABIN7878887

This Mouse Monoclonal antibody specifically detects QKI in WB, IF, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for QKI antibody (full length) (ABIN7878887)

Target: QKI (Protein Quaking (QKI))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This QKI antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Flow Cytometry (FACS)

Clone: PCRP-QKI-2F10

Product Details anti-QKI Antibody

Binding Specificity: full length

Purpose: QKI Antibody / Protein Quaking

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the QKI antibody.

Isotype: IgG2c

Application Details

Application Notes: Optimal dilution of the QKI antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the QKI antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for QKI

Target: QKI (Protein Quaking (QKI))

Alternative Name: QKI

Background: QKI, also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, QKI functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5. Additionally, QKI regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. QKI may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases QKI mRNA-binding affinity. Defects or deletions in the gene encoding QKI are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of QKI exist due to alternative splicing events.

UniProt: Q96PU8