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Recombinant Retinoblastoma Protein (Rb) antibody (full length)

The Rabbit Monoclonal anti-Retinoblastoma Protein (Rb) antibody is suitable to detect Retinoblastoma Protein (Rb) in samples from Human. It has been validated for IHC (p).
Catalog No. ABIN7878912
$640.46
Plus shipping costs $50.00
100 μg
Shipping to: United States
Delivery in 2 to 4 Business Days

Quick Overview for Recombinant Retinoblastoma Protein (Rb) antibody (full length) (ABIN7878912)

Target

See all Retinoblastoma Protein (Rb) (Rb Protein) Antibodies
Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Antibody Type

Recombinant Antibody

Reactivity

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Human

Host

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Rabbit

Clonality

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Monoclonal

Conjugate

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This Retinoblastoma Protein (Rb) antibody is un-conjugated

Application

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade

Carrier-free

Clone

RB1-7080R
  • Binding Specificity

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    full length

    Purpose

    Recombinant Retinoblastoma Antibody (azide and preservative free)

    Purification

    Protein A/G affinity

    Immunogen

    Recombinant human full-length protein was used as the immunogen for the recombinant Retinoblastoma antibody.

    Isotype

    IgG, kappa
  • Application Notes

    Optimal dilution of the recombinant Retinoblastoma antibody should be determined by the researcher.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    Preservative

    Azide free

    Storage

    -20 °C

    Storage Comment

    Aliquot the recombinant Retinoblastoma antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • Target

    Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

    Alternative Name

    Retinoblastoma

    Background

    Recognizes a 105 kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

    UniProt

    P06400

    Pathways

    Mitotic G1-G1/S Phases
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