Recombinant Retinoblastoma Protein (Rb) antibody (full length)
The Rabbit Monoclonal anti-Retinoblastoma Protein (Rb) antibody is suitable to detect Retinoblastoma Protein (Rb) in samples from Human. It has been validated for IHC (p).
Rb Protein
Reactivity: Human, Mouse, Rat, Cow, Dog, Monkey, Pig, Bat, Horse
WB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Optimal dilution of the recombinant Retinoblastoma antibody should be determined by the researcher.
Restrictions
For Research Use only
Format
Liquid
Concentration
1 mg/mL
Buffer
1 mg/mL in 1X PBS, BSA free, sodium azide free
Preservative
Azide free
Storage
-20 °C
Storage Comment
Aliquot the recombinant Retinoblastoma antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Target
Retinoblastoma Protein (Rb) (Rb Protein)
(Retinoblastoma Protein (Rb Protein))
Alternative Name
Retinoblastoma
Background
Recognizes a 105 kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.