Recombinant Retinoblastoma Protein (Rb) antibody (full length)
Quick Overview for Recombinant Retinoblastoma Protein (Rb) antibody (full length) (ABIN7878912)
Target
See all Retinoblastoma Protein (Rb) (Rb Protein) AntibodiesAntibody Type
Reactivity
Host
Clonality
Conjugate
Application
Grade
Clone
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Binding Specificity
- full length
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Purpose
- Recombinant Retinoblastoma Antibody (azide and preservative free)
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Purification
- Protein A/G affinity
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Immunogen
- Recombinant human full-length protein was used as the immunogen for the recombinant Retinoblastoma antibody.
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Isotype
- IgG, kappa
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Application Notes
- Optimal dilution of the recombinant Retinoblastoma antibody should be determined by the researcher.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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Preservative
- Azide free
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Storage
- -20 °C
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Storage Comment
- Aliquot the recombinant Retinoblastoma antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
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Alternative Name
- Retinoblastoma
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Background
- Recognizes a 105 kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.
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UniProt
- P06400
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Pathways
- Mitotic G1-G1/S Phases
Target
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