Recombinant RORC antibody (full length)

Catalog No. ABIN7878935

This Rabbit Monoclonal antibody specifically detects RORC in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant RORC antibody (full length) (ABIN7878935)

Target: RORC (RAR-Related Orphan Receptor C (RORC))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This RORC antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RORC-8278R

Product Details anti-RORC Antibody

Binding Specificity: full length

Purpose: Recombinant ROR gamma Antibody / RORC

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human ROR gamma T protein was used as the immunogen for the recombinant ROR gamma antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant ROR gamma antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles

Storage: -20 °C

Storage Comment: Aliquot the recombinant ROR gamma antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for RORC

Target: RORC (RAR-Related Orphan Receptor C (RORC))

Alternative Name: ROR gamma

Background: Retina-associated orphan receptors (RORs) contains three subtypes: RORAlpha, RORBeta, and RORGamma. They are widely distributed in body tissues, and most of them can directly enter the nucleus to regulate the transcription of target genes, thus showing different tissue specificity and participating in different physiological processes. In particular, RORAlpha and RORGamma play an important role in mediating Th17 cell differentiation. RORGamma can be divided into RORGamma1 and RORGamma2 (RORGamma T), which show different tissue specificity. ROR Gamma (T) is expressed only in lymphoid compartment cells, i.e., CD4+CD8+ double positive thymocytes, peripheral Th17 cells, and lymphoid tissue inducer (LTi) cells of lymphoid organs. At present, RORGamma T is considered as a new target for drug development against autoimmune diseases, especially psoriasis. In recent years, RORGamma T small molecule inhibitors have become a hot research field in academia and even international pharmaceutical companies, with great development potential.

UniProt: P51449

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway