SMNDC1 antibody (full length)

Catalog No. ABIN7879100

This Mouse Monoclonal antibody specifically detects SMNDC1 in FACS and IF. It exhibits reactivity toward Human.

Quick Overview for SMNDC1 antibody (full length) (ABIN7879100)

Target: SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SMNDC1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: PCRP-SMNDC1-1A9

Product Details anti-SMNDC1 Antibody

Binding Specificity: full length

Purpose: SMNDC1 Antibody

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human SMNDC1 protein was used as the immunogen for the SMNDC1 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the SMNDC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SMNDC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for SMNDC1

Target: SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Alternative Name: SMNDC1

Background: SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (survival motor neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.

UniProt: O75940